The Chemical Structure of Sildenafil Citrate
Do not start, stop, or change the dosage of any medicines without your doctor's approval.
How Supplied
Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Tell your doctor if your condition does not get better. May cause dizziness This drug may impair the ability to operate a vehicle, vessel (e.g., boat), or machinery. Use care until you become familiar with its effects. This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Some products that may interact with this drug are: riociguat, vericiguat.
| Parameter | Description | Typical Value |
|---|---|---|
| Absorption Rate | Time to reach peak plasma concentration | 30-120 minutes |
| Bioavailability | Percentage of dose reaching systemic circulation | 40% |
| Half-life | Time to reduce plasma concentration by half | 4 hours |
| Metabolism | Primary site of metabolism | Liver (CYP3A4 enzyme) |
| Excretion | Main routes of elimination | Feces and urine |
Sildenafil can cause a serious drop in your blood pressure when used with nitrates.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Kamagra Oral Jelly | 100mg | 110 + 9 Sachets | 334.87€ 318.92€ | |
| Viagra Generic | 150mg | 10 Pills | 36.73€ 34.98€ | |
| Kamagra Polo | 100mg | 32 Pills | 125.88€ 119.89€ | |
| Viagra Generic | 100mg | 10 Pills | 28.91€ 27.53€ | |
| Viagra Generic | 50mg | 180 + 8 Pills | 158.82€ 151.26€ | |
| Viagra Generic | 25mg | 180 + 6 Pills | 154.93€ 147.55€ | |
| Viagra Generic | 100mg | 20 Pills | 45.58€ 43.41€ | |
| Viagra Generic | 50mg | 10 Pills | 26.87€ 25.59€ | |
| Viagra Generic | 200mg | 120 + 8 Pills | 204.80€ 195.05€ | |
| Kamagra | 100mg | 120 + 6 Pills | 330.74€ 314.99€ | |
| Viagra Generic | 200mg | 10 Pills | 40.96€ 39.01€ | |
| Kamagra Polo | 100mg | 272 + 12 Pills | 622.94€ 593.28€ | |
| Kamagra Polo | 100mg | 84 + 4 Pills | 244.49€ 232.85€ | |
| Viagra Generic | 100mg | 60 + 4 Pills | 96.36€ 91.77€ |
A serious drop in blood pressure can lead to dizziness, fainting, and rarely heart attack or stroke.
Look-Alike Drug Names
Current guidelines for treating pulmonary arterial hypertension in adults call for closely coordinated collaboration between the patient's clinical healthcare team and the providers with expertise in the management of PAH. Sildenafil plays a secondary role as an alternative for patients who demonstrate acute vasoreactivity in WHO functional class II to improve their 6-minute walking distance (6MWD) and those in functional class III to improve 6MWD and improve the functional class. The Serendipitous Story of Sildenafil: An Unexpected Oral Therapy for Erectile Dysfunction. Mitidieri E, Cirino G, d'Emmanuele di Villa Bianca R, Sorrentino R. Pharmacology and perspectives in erectile dysfunction in man.
When to call your doctor
On-Demand Sildenafil as a Treatment for Raynaud Phenomenon: A Series of n-of-1 Trials. Efficacy and Safety of On-Demand Use of 2 Treatments Designed for Different Etiologies of Female Sexual Interest/Arousal Disorder: 3 Randomized Clinical Trials. 2002;4 Suppl 3(Suppl 3):S26-38. The future is today: emerging drugs for the treatment of erectile dysfunction. Fallah F.
When to take
Recent strategies in treatment of pulmonary arterial hypertension, a review. 2015 Jan 26;7(4):307-22. Muirhead GJ, Wulff MB, Fielding A, Kleinermans D, Buss N. Pharmacokinetic interactions between sildenafil and saquinavir/ritonavir. Han MK, Bach DS, Hagan PG, Yow E, Flaherty KR, Toews GB, Anstrom KJ, Martinez FJ., IPFnet Investigators. Do not use sildenafil with any of the following: certain drugs used to treat chest pain/angina (nitrates such as nitroglycerin, isosorbide), recreational drugs called "poppers" containing amyl or butyl nitrite.
How should this medicine be used?
Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. Sildenafil is also available in other brands and strengths for high blood pressure in the lungs (pulmonary hypertension). chronic kidney disease stage 4 (severe) GFR 15-29 mL/min chronic kidney disease stage 5 (failure) GFR<15 mL/min kidney disease with likely reduction in glomerular filtration rate (GFR) Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. If you are also taking an alpha blocker medication (such as doxazosin, tamsulosin) to treat an enlarged prostate/BPH or high blood pressure, your blood pressure may get too low which can lead to dizziness or fainting. Your doctor may start treatment with a lower dose of sildenafil to minimize your risk of low blood pressure. Other medications can affect the removal of sildenafil from your body, which may affect how sildenafil works. Examples include azole antifungals (such as itraconazole, ketoconazole), macrolide antibiotics (such as clarithromycin, erythromycin), mifepristone, rifampin, ritonavir, among others.
- Sildenafil is not recommended for children or minors.
- Elderly patients may need lower doses due to sensitivity.
- Use with caution if you have a history of stroke or unstable angina.
- Combining sildenafil with other ED drugs increases side effects risks.
- Be aware of counterfeit or substandard sildenafil products.
- Always purchase medication from reputable pharmacies.
- Consult a healthcare professional prior to initiating therapy.
Do not take this medication with any other product that contains sildenafil or other similar medications for erectile dysfunction-ED or pulmonary hypertension (such as tadalafil, vardenafil).
- Sildenafil citrate is manufactured by several pharmaceutical companies.
- Its chemical formula is C22H30N6O4S.
- It has a half-life of approximately 4 hours in the body.
- The drug enhances nitric oxide activity in the corpus cavernosum.
- It’s important to follow prescribed dosing to avoid adverse effects.
- It is classified as a phosphodiesterase type 5 inhibitor.
- Sildenafil was initially researched for angina before ED use.
Store at room temperature away from light and moisture. Keep all medications away from children and pets.
Brand names
Patients should also receive monitoring for signs and symptoms of pulmonary edema when treating pulmonary arterial hypertension. In healthy subjects, research demonstrated that single doses up to 800 mg had adverse effects similar to those seen in lower doses but with increased frequency and severity. There are no antidotes available for sildenafil. In case of overdose, patients should receive supportive care. Dose-related visual disturbances occurred more frequently at toxic levels, while blood pressure changes showed a low correlation.
What can I do to make Viagra work faster?
[22] As sildenafil is highly bound to plasma proteins and not excreted renally, dialysis does not help expedite sildenafil clearance. When considering the duration of toxicity, the activity of N-desmethyl-sildenafil must be regarded as this metabolite retains PDE5 specificity at lower potency, with plasma concentrations approaching 40% of the parent compound. Sildenafil is a safe therapeutic option for erectile dysfunction and PAH that has been available on the market for over two decades. Some barriers to successful sildenafil therapy in the treatment of erectile dysfunction include cost and social stigma surrounding erectile dysfunction. [23] All members of the interprofessional health team (clinicians, mid-level practitioners, nurses, and pharmacists) can help eliminate these barriers through compassionate education, a thorough review of systems during clinic visits, and establishing an open line of communication with the patient to better address his medical needs.
Other Interactions
This will result in better patient outcomes, increased quality of life, and fewer adverse events. The use of sildenafil in the management of erectile dysfunction can significantly impact patient quality of life. ED is associated with depression, anxiety, and loss of self-esteem. A small placebo-controlled 12-week study performed on 512 men with erectile dysfunction used the Self Esteem and Relationship (SEAR) questionnaire to assess the impact of sildenafil treatment on patients. The trial results revealed that sildenafil had improved depression, anxiety, and self-esteem. Do not flush medications down the toilet or pour them into a drain unless instructed to do so.
- Sildenafil is available in most countries through prescription only.
- It is used worldwide, with varying approval statuses.
- FDA and EMA have rigorous testing standards for sildenafil.
- Using the drug responsibly can lead to successful treatment outcomes.
- Combining sildenafil with other medications requires medical supervision.
- Be aware of the potential for drug interactions with heart or blood pressure meds.
- Always consult a healthcare professional for personalized advice.
Properly discard this product when it is expired or no longer needed.
Patient Counseling Information
Therapy for Pulmonary Arterial Hypertension in Adults: Update of the CHEST Guideline and Expert Panel Report. Disclosure: Benjamin Smith declares no relevant financial relationships with ineligible companies. Disclosure: Mary Babos declares no relevant financial relationships with ineligible companies. Sildenafil is used to treat male sexual function problems (impotence or erectile dysfunction-ED). In combination with sexual stimulation, sildenafil works by increasing blood flow to the penis to help a person get and keep an erection.
Drug Interactions Table
This drug does not protect against sexually transmitted diseases (such as HIV, hepatitis B, gonorrhea, syphilis). To decrease your risk of infection, always use an effective barrier method (latex or polyurethane condom/dental dams) during all sexual activity. Consult your doctor or pharmacist for more details. 25 mg Brand(s): (of Sildenafil Tablets film-coated sildenafil)* Viagra(R), Pfizer 50 mg Brand(s): (of Sildenafil Tablets Pfizer sildenafil)* Viagra(R), Pfizer 100 mg Brand(s): (of Sildenafil Tablets Pfizer sildenafil)* Viagra(R), Pfizer Read the Patient Information Leaflet if available from your pharmacist before you start taking sildenafil and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
What are the most common side effects of sildenafil?
To treat erectile dysfunction-ED, take this drug by mouth as directed by your doctor, usually as needed. Take sildenafil at least 30 minutes, but no more than 4 hours, before sexual activity (1 hour before works best). This medication may take longer to start working if you take it with a high-fat meal. Do not take more than once daily as needed. The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Consult your pharmacist or local waste disposal company. Ask a clinical question and tap into Healio AI's knowledge base.
| Storage Condition | Details | Temperature Range | Light Exposure | Humidity |
|---|---|---|---|---|
| Preferred Storage | Cool, dry place | 15-30°C | Keep in original container | Avoid humidity |
| Keep away from light | Protect from direct sunlight | N/A | Yes | N/A |
| Out of reach of children | Safety precaution | N/A | N/A | N/A |
Healio's exclusive daily news coverage of clinical data Selected from data included with permission and copyrighted by FDB, Inc.
Precautions with Alcohol
Sildenafil preserves exercise capacity in patients with idiopathic pulmonary fibrosis and right-sided ventricular dysfunction. Treatment of pulmonary arterial hypertension in pregnancy. Cardiovascular safety of sildenafil citrate (Viagra): an updated perspective. Pharmacology and drug interaction effects of the phosphodiesterase 5 inhibitors: focus on alpha-blocker interactions. Ghofrani HA, Osterloh IH, Grimminger F.
Revatio for Oral Suspension
Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond. Update on the clinical utility of sildenafil in the treatment of pulmonary arterial hypertension. Drug treatment of pulmonary hypertension in children. Sildenafil and furosemide associated ototoxicity: consideration of drug-drug interactions, synergy, and broader clinical relevance. Giuliano F, Jackson G, Montorsi F, Martin-Morales A, Raillard P.
Viagra and other medications
Safety of sildenafil citrate: review of 67 double-blind placebo-controlled trials and the postmarketing safety database. Rezaee ME, Ward CE, Brandes ER, Munarriz RM, Gross MS. A Review of Economic Evaluations of Erectile Dysfunction Therapies. Althof SE, O'leary MP, Cappelleri JC, Hvidsten K, Stecher VJ, Glina S, King R, Siegel RL., International SEAR Study Group. Sildenafil white sildenafil tablets citrate improves self-esteem, confidence, and relationships in men with erectile dysfunction: Results from an international, multi-center, double-blind, placebo-controlled trial. This copyrighted material has been downloaded from a licensed data provider and is not for distribution in professional health care settings.
| Brand Name | Manufacturer | Formulation Type | Typical Dosage | Notes |
|---|---|---|---|---|
| Viagra | Pfizer | Tablet | 25, 50, 100 mg | Most well-known brand |
| Revatio | Pfizer | Tablet | 20 mg | For pulmonary hypertension |
| Sildenafil Citrate | Various generic manufacturers | Tablet | 25, 50, 100 mg | Generic versions available |
| Kamagra | Ajanta Pharma | Oral Gel | 100 mg | Used off-label in some countries |